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PGRN protects lysosomal function to enhance microglial autophagic flux ...
CSF PGRN levels as a function of rs708384 genotype in two samples. (A ...
PGRN processing into GRNs is mediated by proper lysosome function and ...
PGRN interactions, trafficking, and proteolysis. Several PGRN receptors ...
Schematic summary of differential effects of PGRN deficiency on brain ...
PGRN as an emerging regulator of lipid metabolism in neurodegenerative ...
PGRN exerts different functions on tumor cells and macrophages in human ...
PSAP facilitates PGRN lysosomal targeting from the extracellular space ...
Deficiency in PGRN triggers high blood pressure and vascular ...
PGRN content in LCLs from WT controls and heterozygous and homozygous ...
Role of PGRN in TMZ resistance and/or EDU labeling in S1R1 cells and ...
Progranulin (PGRN) treatment restores vascular function and blood ...
PGRN processing promotes neuronal outgrowth and branching. (A) Time ...
| Schematic summary of the obtained results. Fibroblasts with PGRN ...
-Transduction with PGRN and L-PGRN does not alter the cellular ...
Serum PGRN levels and its correlation with clinical characteristics ...
PGRN and Pcgin increase the lysosomal delivery of mutant HexA. Normal ...
PGRN and its biological effects in pathogenesis of breast cancer ...
Schematic model of the proposed signal pathways of PGRN effect in ...
-Selective transduction of neurons with PGRN and L-PGRN protects ...
PGRN is a lysosome-resident protein important for lysosome function.a ...
| Protein expression of PGRN in aortic tissue in different groups. NC ...
Pgrn induces outgrowth independent of Sort1. (A) Western blot analysis ...
Progranulin (PGRN) structure and its derivative products. PGRN is ...
Cellular PGRN co-localize with Cat L and active cysteine cathepsins in ...
| PGRN enhances microglial phagocytosis. (A) Representative images of ...
PGRN regulates inflammatory responses in the periphery and central ...
Loss of Pgrn decreases neurite outgrowth and branching in primary ...
PGRN is delivered to lysosomes after sortilin-mediated endocytosis ...
Current, known therapeutic drug candidates for restoring CNS PGRN ...
Schematic representation for the principal PGRN and granulin ...
Variability in CSF PGRN levels explained by genetic variants. (A ...
REST repress PGRN promoter activity. (a) Putative REST binding ...
Lysosomal localization of PGRN in mouse brain. Adult brain sections ...
PGRN binds to HexA through granulins G and E. a Co-IP assay to test the ...
PGRN levels are increased in a mouse model of Psap loss. (a) Immunoblot ...
Identification of biological pathways regulated by PGRN and GRN peptide ...
Progranulin Facilitates Conversion and Function of Regulatory T Cells ...
PGRN reduces lysosomal storage in multiple LSDs. Fibroblasts from ...
PGRN immunolabeling following ND-602. (A) Representative... | Download ...
CD68 binds PGRN and granulin E via the mucin-proline-rich domain. A ...
Clinical characteristics and circulating PGRN concentrations in the ...
Increased serum PGRN levels in sortilin-deficient mice. PGRN levels in ...
FTD Patient-Specific Neuronal Model of PGRN Haploinsufficiency ...
| Increased levels of PGRN and PSAP in activated glial cells on injury ...
Working model of PGRN functions presented in the NAc in FTD-like ...
PGRN missense-mutations are impaired in secretion. A , schematic ...
Rescue of a lysosomal storage disorder caused by Grn loss of function ...
Progranulin: normal function and role in neurodegeneration - Eriksen ...
| JIR | Dove Medical Press
Research Summary | The Hu Lab
Progranulin [PGRN] - Marker of Neuroinflammation
A working hypothesis for how the PGRN/PIRO axis regulates the formation ...
| A schematic drawing illustrating the proposed disease mechanism of ...
Progranulin in neurodegenerative dementia - Wang - 2021 - Journal of ...
The Role of Progranulin (PGRN) in the Pathogenesis of Glioblastoma ...
Gene Mutations and Dementia
Lysosomal functions of progranulin and implications for treatment of ...
Proposed model illustrating the multiple signaling pathways by which ...
Possible mechanism of action of progranulin (PGRN) in suppressing ...
Sorting Out Frontotemporal Dementia?: Neuron
Diagram summarizing the progranulin (PGRN) deficiency-related nuclear ...
Frontotemporal dementia: Neural circuits, genetics and neuropathology ...
Progranulin binds to multiple cell surface receptors. (A) Progranulin ...
Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal ...
Progranulin as a therapeutic target in neurodegenerative diseases ...
Progranulin in wound repair and inflammation. On the left of the panel ...
Progranulin: a key player in autoimmune diseases - PMC
Effect of PGRN/GRN on soma size and neurite outgrowth. (A–D) NF-H ...
PGRN/GRN improves neuronal survival. (A) Effect of GRN E on survival of ...
Microglial Progranulin: Involvement in Alzheimer’s Disease and ...
Progranulin functions as a neurotrophic factor to regulate neurite ...
Proposed model for TDP-43 LOF effects on the PGRN-SORT1 axis in murine ...
Molecular Medicine Reports
r-PGRN treatment reduces cerebral infarct volume and brain edema in ...
Progranulin (PGRN) as a regulator of inflammation and a critical factor ...
Summary of our findings. Progranulin (PGRN) activates endothelial ...
The protein and gene structure of a mammalian progranulin. (A ...
Full article: Progranulin as a Potential Therapeutic Target in Immune ...
Autophagy influences PGRN-mediated anabolic, catabolic, proliferation ...
Some Features of PGRN, microglia and Alzheimer's disease. (A) Confocal ...
The serum progranulin (PGRN) levels are elevated in patients with ...
Frontiers | Parkin Levels Decrease in Fibroblasts With Progranulin ...
Progranulin’s Protective Mechanisms and Therapeutic Potential in ...
Cell biology of Progranulin (PGRN) deficiency in microglia. | Download ...
Lysosomal abnormality in PGRN-deficient macrophages. a Representative ...
Lung Epithelial Cells
Frontiers | Progranulin Preserves Autophagy Flux and Mitochondrial ...
(PDF) Insights into the role of progranulin in immunity, infection, and ...
Vascular Contractility Relies on Integrity of Progranulin Pathway ...
Anti-Progranulin Antibody AF2420: R&D Systems
Progranulin as a Novel Factor in Gaucher Disease - eBioMedicine
Progranulin Maintains Blood Pressure and Vascular Tone Dependent on ...
Targeting Progranulin as an Immuno-Neurology Therapeutic Approach
Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in ...
Frontiers | Molecular mechanisms and targeted therapy of progranulin in ...
Passage Bio, Inc. - Our Science - Role of Progranulin
